Withanolides of Datura stramonium

Antiproliferative withanolides from Datura wrightii.

A new withanolide, named withawrightolide (1), and four known withanolides (2-5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1-5 showed antiproliferati...

Poisoning by Datura (Stramonium)— Recovery

partaken of a quantity of datura leaves, prepared in the form of curry, with rice, which he afterwards acknowledged to have voluntarily taken. On admission, he lay perfectly unconscious, with severe spasmodic muscular twitchings and stertorous breathing. Skin cool; pulse about 108?, feeble. Pupils dilated and insensible to the effects of light. The stomach pump was immediately introduced, but d...

Datura stramonium poisoning in children.

Although substance abuse is fairly common among adolescents, poisoning from Datura stramonium (a broadleaf annual erect herb with spine-covered seed capsule) is uncommon in children and has not been reported in our locality. We present the case of two children admitted at the Children Emergency Room of a teaching hospital following ingestion of extract of Datura stramonium. They developed neuro...

Purification of the lectin from Datura stramonium.

The lectin from Datura stramonium can be inhibited by oligomers of N-acetylglucosamine. This property was exploited to purify the lectin by affinity chromatography on Sepharosefetuin. The purified lectin is a glycoprotein in having subunits of 40 000 and 45 000 mol.wt.

Jimson weed (Datura stramonium) poisoning in childhood.